You want to avoid having to continually update the Dockerfile to install necessary system-level dependencies when you add a new Python package. When in doubt, start with a *-slim flavor, especially in development mode, as you're building your application. Refer to The best Docker base image for your Python application and Using Alpine can make Python Docker builds 50× slower for more on why it's best to avoid using Alpine-based base images. As a result, you may end up having to build the binaries yourself, which can increase the image size (depending on the required system-level dependencies) and the build times (due to having to compile from the source). While the Alpine flavor, based on Alpine Linux, is the smallest, it can often lead to increased build times if you can't find compiled binaries that work with it.
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